Barnoldswick are at home to Runcorn in the Vodkat League, while Colne and Ramsbottom are on the road.
Bacup beat Padiham 3-2 in a thriller at the Arbories in midweek and look to build on that at St Helens, while the Storks aim to recover from the loss with a trip to Bootle.
And in the First Division AFC Darwen go to Cheadle Town.
Vodkat League Premier Division: Atherton LR v Colne, Barnoldswick Town v Runcorn Linnets, Bootle v Padiham, New Mills v Ramsbottom United, Rossendale United v Winsford United, St Helens Town v Bacup Borough.
Vodkat First Division: Cheadle Town v AFC Darwen.
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