Josh Brownhill's goal was in vain as Burnley were beaten 3-1 by Arsenal at the Emirates.
The midfielder cancelled out Leandro Trossard's opener, but goals from William Saliba and Oleksandr Zinchenko gave the hosts all three points.
Bukayo Saka, deemed fit enough to start despite limping off in the midweek win against Sevilla, had a great effort well saved by James Trafford as Arsenal set their stall out to attack from the off.
They would be frustrated, however, by a Burnley defence already at the stage of throwing themselves in front of shots and making last-ditch blocks before the half-hour mark, Saka time and again finding space and Kai Havertz also drifting in to cause trouble.
Havertz, still without a goal from open play since his £65million move from Chelsea, headed wide a glorious chance from a corner before Burnley threatened for the first time.
A rare mistake from Saliba gifted the ball to Johann Berg Gudmundsson, who raced through on goal to force David Raya into a low stop.
Trossard was the next Arsenal player denied by Trafford, his effort from range tipped over the bar after Declan Rice had robbed Brownhill of possession in a dangerous area of the pitch.
The Belgium international was deployed as a central striker once again and gave the hosts the lead with his sixth goal of the campaign, turning home Saka’s header from close-range as he crashed into Trafford and the frame of the goal in the process.
Burnley were level nine minutes after the restart, Brownhill firing home after good work from Luca Koleosho led to the ball breaking for Brownhill, whose finish flashed in off Gabriel Magalhaes.
The goal stood despite a VAR check for a potential foul on Takehiro Tomiyasu but to Arsenal’s credit, they did not let the equaliser play on their minds.
In fact, the goal seemed to stun Arsenal back into life and Gabriel Martinelli broke clear only to fire straight at Trafford.
The lead was restored from the resulting corner as Saliba moved in front of Trafford to rise and head home Trossard’s delivery from close-range.
Zinchenko’s strike came from another Trossard corner as Dara O’Shea first headed the ball against his own crossbar before clearing into the path of the Ukraine captain, who finished acrobatically.
Burnley tried to find a way back into the game and were given some hope when substitute Vieira was dismissed, shown a straight red card by Michael Oliver for a high challenge on Brownhill.
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